Comparative Genomics Group
实验室概况 导师简介 研究方向 最新进展 团队成员


 

 

 

 

宿兵


中国科学院知识创新工程学科带头人,中科院“百人计划”引进人才,理学博士,研究员,博士生导师;昆明动物所副所长;细胞与分子进化院重点实验室主任。从事灵长类比较基因组学、现代人类起源和迁徙以及人类智慧起源的遗传学机制研究。已在《Science 》、《Nature 》、《Nature Reviews Genetics 》、《PNAS 》、《American Journal of Human Genetics 》、《Genome Research 》《Human Molecular Genetics 》和《Molecular Biology and Evolution 》等国际核心刊物上发表论文60 余篇

学习和研究经历:

1985.91989.7:本科,武汉大学生物系细胞生物学专业。

1991.91996.7: 博士,中国科学院昆明动物研究所(导师:施立明院士)。

1994.81995.2: 访问学生,美国加州大学圣地亚哥分校生物系。

1996.81997.8: 副研究员,中国科学院昆明动物研究所。

1997.92000.2: 博士后,美国德克萨斯大学修斯顿人类遗传学中心。

2000.32001.5: Research Fellow, 美国德克萨斯大学修斯顿人类遗传学中心。

2000.3 - 2001.5: Research Fellow, 美国德克萨斯大学修斯顿人类遗传学中心。

2001.5 - 2004.8: Assistant Professor, 美国辛辛那提大学医学院。

2001.9 -:中国科学院昆明动物所研究员。

 

曾获奖励

1996:中国科学院自然科学奖一等奖(第三完成人)项目名称:中国特有珍稀动物类群的细胞和分子进化。

1997:国家自然科学奖三等奖(第三完成人)项目名称:中国特有珍稀动物类群的细胞和分子进化。

2002: 云南省自然科学一等奖(第三完成人)滇金丝猴生物学研究

2003: 教育部科技进步一等将(第三完成人)东亚人群的起源和史前迁徙研究

2005 :云南省自然科学一等奖中国少数民族DNA 库的建立及应用研究

 
正在主持的科研项目:

1.中国科学院百人计划(2001-2004)(2004 年终期评估获得优秀和追加经费支持)
2. 国家高技术研究发展计划(863 计划)-云南具有疾病相关表型隔离人群遗传资源的收集和研究(2002-2004)
3.国家基金委面上项目--云南元谋新石器时代有群的古DNA及其源流研究(2004-2006)
4.云南省科委面上基金--Neuropsin基因的分子进化与灵长类认知起源的分子机制(2004-2006)
5.国家基金委主任基金-人类和非人灵长类大脑前额叶基因表达谱的比较及人类起源的遗传学机制研究(2004-2005)
6.中科院重要创新方向项目-基因组新结构和新功能发生的进化遗传学机制(2004-2006)
7.国家基金委杰出青年基金-人类起源的遗传学机制研究 (2006-2010)
8.国家基金委重点项目-灵长类大脑进化的遗传机制研究 (2007-2011)
9. 科技部973 项目-非人灵长类动物克隆及治疗性克隆的机理研究(2006-2010)

 

发表论文(至2007年5月)

  1. Lu ZX, Peng J, Su B. 2007 A human specific mutation leads to the origin of a novel splice form of neuropsin, a gene involved in learning and memory. Human Mutation (in press)<文章下载>
  2. Zhang Q, Zhang F, Chen XH, Wang YQ, Wang WQ, Lin AA, Cavalli-Sforza LL, Jin L, Huo R, Sha JH, Su B. 2007 Rapid evolution, genetic variations and functional association of the human spermatogenesis related gene NYD-SP12. J. Mol. Evol. (in press)
  3. Liao CH, Kuang YQ, Zheng YT, Su B. 2007 A novel fusion gene mnTRIMCyp in pig-tailed macaque determines its susceptibility to HIV-1 infection. AIDS (in press).
  4. Zhang R, Peng Y, Wang W, Su B. 2007 Rapid evolution of a X-linked microRNA cluster in primates. Genome Research 17:612-617.<文章下载>
  5. Wang W, Zhong J, Su B, Zhou Y, Wang YQ. 2007 Comparison of Pax1/9 locus reveals 500-Million-Year-Old syntenic block and evolutionary conserved non-coding regions. Mol. Bio. Evol. 24:784-791.<文章下载>
  6. Qi XB, Yang S, Zheng HK, Wang YQ, Liao CH, Liu Y, Chen XH, Shi H, Yu XJ, Lin AA, Cavalli-Sforza, Wang J, Su B. 2007 Detecting positive Darwinian selection in brain-expressed genes during human evolution. Chinese Science Bulletin 52:324-335.<文章下载>
  7. Yu XJ, Zheng HK, Wang J, Wang W, Su B. 2006 Detecting lineage specific adaptive evolution of brain-expressed genes in human using rhesus macaque as outgroup. Genomics 88:745-751.<文章下载>
  8. Li Y, Su B. 2006 No accelerated evolution of 3'UTR region in human for brain-expressed genes. Gene 383:38-42.<文章下载>
  9. Chen XH, Su B. 2005 The testis-specific apoptosis related gene TTL.6 underwent adaptive evolution in the lineage leading to humans. Gene 370: 58-63.<文章下载>
  10. Chen XH, Su B . 2005 The testis-specific apoptosis related gene TTL.6 underwent adaptive evolution in the lineage leading to humans. Gene (in press)
  11. Liu Y, Yang S. Lin AA, Cavalli-Sforza LL, Su B . 2005 Molecular evolution of CXCR1, a G protein coupled receptor involved in signal transduction of neutrophils. J. Mol. Evol. 61:691-696. <文章下载>
  12. Liu HL, Wang YQ, Liao CH, Kuang YQ, Zheng YT , Su B . 2005 Adaptive Evolution of Primate TRIM5α, a Gene Restricting HIV-1 Infection. Gene 362:109-116. <文章下载>
  13. Wang W, Xu HL, Lin LP, Su B , Wang YQ 2005 Construction of a BAC library for Chinese amphioxus Branchiostoma belcheri and identification of clones containing Amphi-Pax genes. Genes Genet. Syst. 80: 233-236. <文章下载>
  14. Shi H, Dong YL, Wen B, Xiao CJ, Underhill PA, Shen PD, Chakraborty R, Jin L and Su B . 2005 Y chromosome evidence of southern origin of the East Asian specific haplogroup O3-M122. Am. J. Hum. Genet. 77: 408-419.<文章下载>
  15. Yang S, Liu Y, Lin AA, Cavalli-Sforza LL, Zhao ZM, Su B. 2005 Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in Nociception. Gene <文章下载>
  16. Wang YQ, Qian YP, Yang S, Shi H, Liao CH, Zheng HK, Wang J, Lin AA, Cavalli-Sforza LL, Underhill
  17. PA,Chakraborty R, Jin L, Su B. 2005 Accelerated evolution of the PACAP precursor gene during human
  18. origin.Genetics. <文章下载>
  19. Ma LY, Marmor M, Zhong P, Ewane L, Su B, Nyambi P. 2005 Distribution of CCR2-64I and SDF1- 3’A Alleles and HIV Status in 7 Ethnic Populations of Cameroon. J AIDS <文章下载>
  20. Liu Z, Wang Y, Su B. 2005The mitochondrial genome organization of the rice frog, Fejervarya limnocharis (Amphibia: Anura): a new gene order in the vertebrate mtDNA. Gene <文章下载>
  21. Xu HL, Su B. 2005 Genetic evidence of strong functional constraint of neurotrypsin during primate evolution. Cytogenetic and Genome Research. 108:303-309 <文章下载>
  22. Wen B, Xie X, Gao S, Li H, Shi H, Song X, Qian T, Xiao C, Jin JZ, Su B , Lu DR, Chakraborty R, Jin L. 2004 Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in Southern Tibeto-Burmans. Am. J Hum Genet. 74:856-865. <文章下载>
  23. Wen B, Li H, Gao S, Mao X, Gao Y, Li F, Zhang F, He Y, Dong Y, Zhang ,Y, Huang W, Jin J, Xiao C, Lu D,Chakraborty R, Su B, Deka R, Jin L. 2004. Genetic structure of Hmong-Mien speaking populations in East Asia As revealed by mtDNA lineages. Mol. Biol. Evol. (published online on November 17, 2004)<文章下载>
  24. Li Y, Qian YP, Yu XJ, Wang YQ, Dong DG, Sun W, Ma RM, Su B 2004 Recent origin of a hominoid specific splice form of neuropsin, a gene involved in learning and memory. Mol. Bio. Evol. 21:2111-2115.<文章下载>
  25. Wen B, Li H, Lu D, Song X, Zhang F, LiF, Gao Y, Mao X, Zhang L, Qian J, Tan J, Jin J, Huang W, Deka R, Su B, Chakraborty R, Jin L. 2004 Genetic evidence supports demic diffusion of Han people. Nature 431:302-305.<文章下载>
  26. Wang YQ, Su B. 2004 Molecular evolution of microcephalin, a gene determining human brain size. Human Molecular Genetics 13:1131-1137.<文章下载>
  27. Qian, YP, Jin L, Su B. 2004 Construction and characterization of bacterial artificial chromosome library of black-handed spider monkey (Ateles geoffroyi)Genome47(2): 239-245. <<文章下载>
  28. Xu HL., Qian YP., Nie WH., Chi JX., Yang FT., Su B. 2004Construction, characterization and chromosomal mapping of bacterial artificial chromosome (BAC) library of Yunnan snub-nosed monkey (Rhinopithecus bieti). Chromosome Research 12:251-262.<文章下载>
  29. Lell, JT., Sukernik, RI., Starikovskaya, YB., Su B. et al. 2002 The dual origin and Siberian affinities of Native American Y chromosomes. American Journal of Human Genetics 70:192-206.
  30. Wells RS, Yuldasheva NY, Ruzibakiev RM, Underhill PA, Evseeva I, Blue-Smith J, Jin L, Su, B. et al. 2001 The Eurasian heartland:A continental perspective on Y-chromosome diversity. PNAS 98:10244-10249.
  31. Ramana GV, Vasanthi A, Khaja M, Su B et al. 2001 Distribution of HIV-I resistance-conferring polymorphic alleles SDF-1-3’A, CCR2-64I and CCR5-32 in diverse populations of Andhra Pradesh, South India. J. of Genet. 80:137-140
  32. Ramana GV, Su B. et al. 2001 Y-chromosome SNP haplotypes suggest evidence of gene flow among caste, tribe, and the migrant Siddi populations of Andhra Pradesh, SouthIndia. Eur. J. Hum. Genet. 9:695-700.<文章下载>
  33. Jin L and Su B. (评论)2001 The Y chromosome and the replacement hypothesis. Science 293:567-568. <文章下载>
  34. Ke YH, Su B. et al. 2001 No independent origin of modern humans in East Asia: a tale of 12,000 Y chromosomes. Science 292:1151-1153. <文章下载>
  35. Su B et al. 2001 Genetic diversity and population history in Red Panda (Ailurus fulgens) as inferred from mitochondrial DNA sequence variations. Mol. Bio. Evol. 18:1070-1076.<文章下载>
  36. Akey, J.M.;Sosnoski, D.;Parra, E.;Dios, S.;Hiester, K.;Su, B. et al. 2001 Melting Curve Analysis of SNPs (McSNP): A Gel-Free and Inexpensive Approach for SNP Genotyping. BioTechniques 30:358-367
  37. Ke, YH., , Su, B et al. 2001 Y-chromosome haplotype distribution in Han Chinese populatiions and modern human origin in East Asians. Science in China (Series C) 44:225-232.
  38. Ke, YH., Su, B et al. 2001 Y-chromosome evidence for no independent origin of modern human in China. Chinese Science Bulletin 46:935-937.
  39. Peterson, B., Su, B et al., 2000 World population data for the HLA-DQA1,PM and D1S80 loci with least and most common profile frequencies for combinations of loci estimated following NRC II guidelines. Journal of Forensic Science. 45 (1):118-146
  40. Jin L and Su B. 2000 Natives or Immgrants: Modern human origin in East Asia. Nature Reviews Genetics 1:126-133. <文章下载>
  41. Su,B et al. 2000 Y chromosome haplotypes reveal prehistorical migrations to the Himalayas. Human Genetics 107:582-590.<文章下载>
  42. Su, B et al.2000Distributions of three HIV-1 resistant polymorphisms (SDF1-3'A, CCR2-64I, and CCR5-D32) in Global Populations.European Journal of Human Genetics 8:939-945.<文章下载>
  43. Su,B et al. 2000 Polynesian Origins: New Insights from the Y-chromosomeProceedings of NationalAcademy of Sciences (PNAS), USA 97:8225-8228. <文章下载>
  44. Qian YP, Qian BZ, Su B. 2000 Multiple Origins of Tibetan: Y Chromosome Evidences. Human Genetics 106:453-454.<文章下载>
  45. Su, B et al. 1999 Y Chromosome evidence for a Northward Migration of Modern Humans into East Asia during the Last Ice Age. American Journal of Human Genetics 65:1718-1724. <文章下载>
  46. Su, B et al. 1999 Distribution of two HIV-1 resistant polymorphisms (SDF1-3'A and CCR2-64I) in East Asia and world populations and its implication in AIDS epidemiology. American Journal of Human Genetics 65:1047-1053. <文章下载>
  47. Su, B et al. 1999 Phylogenetic study of complete cytochrome b genes of musk deer (genus Moschus ) using museum samples. Molecular Phylogentics and Evolution 12:241-249. <文章下载>
  48. Chakraborty, R., Stivers, DN. and d Su, B et al., 1999 The utility of short tandem repeat loci beyond human identification: Implications for development of new DNA typing systems. Electrophresis 20:1682-1696
  49. Su, B et al. 1998 Frequency of an HIV-resistant allele is exceptionally high in New Guinea Highlanders. Journal of the American Medical Association, JAMA. 280:1830. <文章下载>
  50. Hu, WP., Lian, LS., Su, B et al 1998 Genetic diversity of Yunnan local pig breeds inferred from blood protein electrophoresis. Biochemical Genetics. 36:207-212.
  51. Lan, R., Hong, QH., Gao YH., Zhang J., Su, B. et al. 1998 Mitochondrial DNA polymorphism in sheep from Yunnan. Hereditas. 20(1): 20-23.
  52. Su, B. et al. 1997 Genetic diversity and molecular phylogeny of slow lorris ( Genus Nycticebus ) Primates 39(1): 79-94 <文章下载>
  53. Su, B. et al. 1997 Protein variation and genetic divergence of Chinese macaques (Genus Macaca) . Chinese Journal of Genetics.
  54. Chen, YJ., Wang, W., Su, B. et al. 1997 Genetic divergence of Cordyceps sinensis as estimated by random amplified polymorphic DNA analysis. Chinese Journal of Genetics. 24(5): 410-416.
  55. Xiao, WH., ,Su, B. et al. 1997 A simple method for getting digoxigenin labeling probe of mtDNA form ovary of fish. Zoological Research. 18(1): 72- 78
  56. Yu, Y. Wen, JK., Zhu, FX., Zhao, KD., Su, B. et al. 1997 Genetic diversity of Wenshan and Diqing yellow cattle in Yunnan province assayed by protein electrophoresis. Zoological Research. 18(3): 333-339.
  57. Su, B . et al. 1996 Molecular phylogeny of Chinese concolor gibbons. Science in China . 26(5): 414-419 <文章下载>
  58. Su, B., Chen, Z. P., et al. 1996 Protein polymorphism and genetic differentiation in three species of Apodemus from Yunnan. Zoological Research. 17:259-262.
  59. Wang, W. Su, B et al., 1996 Interspecific differentiation of the slow lorses (Genus Nycticebus) inferred from ribosomal DNA restriction maps. Zoological Research. 17(1): 89-93.
  60. Nie, L., Chen, YJ., Wang, W., , Su, B. et al 1996 Mitochondrial DNA polymorphism in Xuwen yellow cattle and Hainan yellow cattle. Zoological Research. 17(3): 269-274.
  61. Wang, W., Su, B. et al., 1996 Phylogenetic relationships among six species of Macaca inferred from ribosomal DNA variations. Chinese Journal of Genetics. 23(4): 247-253.
  62. Su,B et al. 1995 Genetic diversity in the snub-nosed monkey ( Rhinopithecus bieti ) as estimated by protein electrophoresis. Conservation Biology 9(4): 847-851. <文章下载>
  63. Su, B., Liu, A. H. et al. 1995 Protein polymorphism and genetic differentiation in Yunnan common horse and short horse populations. Zoological Research. 16(2): 126-131
  64. Wang W, Su B et al., 1995 Phylogenetic relationship among two species of golden monkey and three species of leaf monkey inferred from ribosomal DNA variation. Folia Primatologica 65:138-143
  65. Wang, W., Lan, H., ,Su, B. et al., 1995 Analysis of randomly amplified polymorphic DNAs for four minorities in Yunnan province. Chinese Science Bulletin. 40(2): 158-163.
  66. Su, B et al., 1994 Genetic diversity in Chinese pangolin (Manis pentadactyla) based on protein electrophoresis. Biochemical Genetics 32:343-349.
  67. Su, B et al., 1994 Genetic diversity of giant panda: evidence from protein electrophoresis. Chinese Science Bulletin 39(8):742-745 <文章下载>

 

 

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